Description

(2'R)- 2'-Deoxy-2'-Fluoro-2'-Methylcytidine 3',5'-Bis(2-Methylpropanoate) CAS NO 940908-79-2 is a high-purity, fluorinated nucleoside derivative that serves as a critical advanced intermediate in pharmaceutical research and development. This compound is valued for its role in the synthesis of modified oligonucleotides and potential antiviral or anticancer therapeutics, where its specific stereochemistry and protective groups are essential for precise biological activity. It is primarily utilized by research institutions, pharmaceutical companies, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the development of novel nucleoside-based drugs and diagnostic probes.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used in the research and development of modified antisense oligonucleotides (ASOs) and siRNA molecules.
• Prodrug Development: Serves as a protected precursor in the design of prodrugs to enhance bioavailability and targeted delivery.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to investigate the impact of 2'-fluoro-2'-methyl modifications on nucleoside pharmacology.
• Biochemical Tool Development: Utilized in creating labeled probes and substrates for enzymatic studies and diagnostic assays.
• Process Chemistry & Scale-Up: Serves as a critical intermediate for process optimization and GMP-scale manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(2'R)- 2'-Deoxy-2'-Fluoro-2'-Methylcytidine 3',5'-Bis(2-Methylpropanoate)
CAS No.	940908-79-2
Molecular Formula	C₁₈H₂₇FN₄O₆
Molecular Weight	414.43 g/mol
Synonyms	2'-Deoxy-2'-fluoro-2'-C-methylcytidine 3',5'-diisobutyrate; (2'R)-2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate); 2'-Fluoro-2'-C-methylcytidine 3',5'-diisobutyrate; PSI-6130 diisobutyrate; RO2433 diisobutyrate; β-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine 3',5'-diisobutyrate; 1-(3,5-Di-O-isobutyryl-2-deoxy-2-fluoro-2-C-methyl-β-D-ribofuranosyl)cytosine
EINECS	Contact for details

Quality Control

Our (2'R)- 2'-Deoxy-2'-Fluoro-2'-Methylcytidine 3',5'-Bis(2-Methylpropanoate) is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and pharmaceutical development. Products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each batch to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.