Description

3-(2,5-Dichloropyrimidin-4-Yl)-1H-Indole is a high-purity, advanced pharmaceutical intermediate featuring a versatile indole-pyrimidine hybrid structure. This compound matters for its critical role as a key building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new drug candidates, especially those targeting kinase inhibition and other therapeutic pathways.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of potential drug candidates, particularly in oncology and anti-inflammatory research.
• Medicinal Chemistry Research: Serves as a core scaffold for constructing compound libraries for high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• Kinase Inhibitor Development: The dichloropyrimidine moiety makes it a valuable synthon for developing selective kinase inhibitors.
• Chemical Biology Probes: Used in the design and synthesis of molecular probes to study specific biological processes and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic chemistry and novel heterocycle development.

Basic Information

Product Name	3-(2,5-Dichloropyrimidin-4-Yl)-1H-Indole
CAS No.	937366-57-9
Molecular Formula	C12H7Cl2N3
Molecular Weight	264.11 g/mol
Synonyms	1H-Indole, 3-(2,5-dichloro-4-pyrimidinyl)-; 3-(2,5-Dichloro-4-pyrimidinyl)-1H-indole; 3-(2,5-Dichloropyrimidin-4-yl)indole; 4-(1H-Indol-3-yl)-2,5-dichloropyrimidine; 2,5-Dichloro-4-(1H-indol-3-yl)pyrimidine; 937366-57-9 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 3-(2,5-Dichloropyrimidin-4-Yl)-1H-Indole is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques. We support our partners with full traceability and documentation to meet the stringent requirements of pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture and contamination.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.