Description

Methyl 5-(Trimethylsilyl)-1H-Pyrazole-3-Carboxylate CAS NO 936368-98-8 is a high-purity, functionalized pyrazole derivative featuring a trimethylsilyl (TMS) protecting group and a methyl ester moiety. This compound serves as a versatile and critical building block in advanced organic synthesis, enabling the construction of complex heterocyclic scaffolds. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the pyrazole core's bioactivity.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands used in catalysis and material science.
• Functional Material Development: Employed in the research and production of advanced organic electronic materials and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic & Industrial R&D: Essential for methodological studies in organic chemistry, including new reaction development and heterocycle functionalization.

Basic Information

Product Name	Methyl 5-(Trimethylsilyl)-1H-Pyrazole-3-Carboxylate
CAS No.	936368-98-8
Molecular Formula	C9H16N2O2Si
Molecular Weight	212.33 g/mol
Synonyms	Methyl 5-(trimethylsilyl)-1H-pyrazole-3-carboxylate; 1H-Pyrazole-3-carboxylic acid, 5-(trimethylsilyl)-, methyl ester; Methyl 5-trimethylsilyl-1H-pyrazole-3-carboxylate; 5-(Trimethylsilyl)-1H-pyrazole-3-carboxylic acid methyl ester; 3-Carbomethoxy-5-(trimethylsilyl)pyrazole; TMS-Pyrazole ester
EINECS	Contact for details

Quality Control

Our Methyl 5-(Trimethylsilyl)-1H-Pyrazole-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to cGMP and ISO standards guarantees a reliable supply of high-purity material for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.