Description

Potassium (4-tert-Butoxycarbonylpiperazin-1-yl)methyltrifluoroborate is a versatile and highly valuable organotrifluoroborate reagent, a key building block in modern synthetic chemistry. Its primary value lies in its exceptional stability and utility in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, where it is used to introduce functionalized piperazine motifs into target molecules with high precision and yield.

Application

• Pharmaceutical Intermediate Synthesis: A critical reagent for constructing complex drug candidates, particularly those containing protected piperazine scaffolds, via palladium-catalyzed cross-coupling.
• Agrochemical Research & Development: Used in the synthesis of novel active ingredients for crop protection, leveraging the stability of the trifluoroborate group.
• Material Science & Chemical Biology: Serves as a building block for creating functionalized polymers, ligands, and bioconjugates for advanced applications.
• Medicinal Chemistry & Lead Optimization: Enables rapid parallel synthesis and structure-activity relationship (SAR) studies by providing a stable handle for diversification.
• Process Chemistry & Scale-up: Its bench-stable nature makes it suitable for the development of robust and scalable manufacturing routes for active pharmaceutical ingredients (APIs).
• Academic Research: A fundamental tool in methodology development for new C-C bond-forming reactions and catalysis studies.

Basic Information

Product Name	Potassium (4-tert-Butoxycarbonylpiperazin-1-yl)methyltrifluoroborate
CAS No.	936329-97-4
Molecular Formula	C10H19BF3KN2O2
Molecular Weight	294.08 g/mol
Synonyms	Potassium (Boc-piperazinyl)methyltrifluoroborate; Potassium [(4-tert-Butoxycarbonylpiperazin-1-yl)methyl]trifluoroborate; Potassium Trifluoro[(4-((tert-butoxycarbonyl)piperazin-1-yl)methyl]borate; (Boc-Piperazin-1-ylmethyl)trifluoroborate Potassium Salt; N-Boc-4-(Trifluoroboratomethyl)piperazine Potassium Salt; Potassium (N-Boc-piperazin-4-ylmethyl)trifluoroborate; Potassium (1-Boc-piperazin-4-yl)methyltrifluoroborate; Potassium (4-Boc-piperazin-1-ylmethyl)trifluoroborate
EINECS	Contact for details

Quality Control

Our Potassium (4-tert-Butoxycarbonylpiperazin-1-yl)methyltrifluoroborate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹⁹F, ¹¹B), HPLC, and KF titration, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere. Due to its hygroscopic (moisture-sensitive) nature, the container should be opened only under dry conditions and resealed immediately after use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
NMR Purity (¹H NMR)	≥ 95%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.