Description

2-Nitro-4-[(trifluoromethyl)sulphanyl]phenol, also known as 4-hydroxy-3-nitrophenyl trifluoromethyl sulphide, is a specialized aromatic compound featuring a unique trifluoromethylthio (-SCF₃) substituent. This structural motif is highly valued in advanced chemical synthesis for its ability to impart significant lipophilicity and metabolic stability to target molecules. It serves as a critical building block for researchers and manufacturers in the pharmaceutical and agrochemical industries, enabling the development of novel active ingredients with enhanced properties.

Application

This compound is primarily utilized as a sophisticated synthetic intermediate. Its applications are centered around the introduction of the pharmacologically privileged trifluoromethylthio group into more complex molecular architectures.

• Pharmaceutical Intermediate: Key precursor in the research and development of new drug candidates, particularly for bioactive molecules requiring enhanced membrane permeability and metabolic resistance.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the -SCF₃ group improves biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced organic materials.
• Ligand and Catalyst Development: Employed in organometallic chemistry for synthesizing novel ligands that can modify catalyst properties.

Basic Information

Product Name	2-Nitro-4-[(trifluoromethyl)sulphanyl]phenol
CAS No.	933673-33-7
Molecular Formula	C₇H₄F₃NO₃S
Molecular Weight	239.17 g/mol
Synonyms	4-Hydroxy-3-nitrophenyl trifluoromethyl sulphide; 2-Nitro-4-(trifluoromethylthio)phenol; 3-Nitro-4-(trifluoromethylthio)phenol; Phenol, 2-nitro-4-[(trifluoromethyl)thio]-; 4-(Trifluoromethylsulfanyl)-2-nitrophenol; 933673-33-7; 4-Hydroxy-3-nitrophenyl trifluoromethyl sulfide
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for all our fine chemical intermediates. Each batch of 2-Nitro-4-[(trifluoromethyl)sulphanyl]phenol is analyzed to ensure it meets high-purity standards suitable for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. Our quality system supports traceability and consistency, which is critical for your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider using an inert atmosphere (e.g., nitrogen or argon) to maintain product integrity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.