Description

3-Bromo-5-Chloro-2-Iodotoluene is a halogenated toluene derivative of significant interest in advanced organic synthesis. This compound serves as a versatile and valuable multi-functionalized aromatic building block, enabling the precise construction of complex molecular architectures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those requiring halogenated aromatic cores for bioactivity or as coupling points for further derivatization.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where the specific halogen pattern can influence biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functional unit in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine and bromine substituents make it an excellent substrate for sequential palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira), allowing for controlled, modular synthesis.
• Chemical Library Development: Employed in high-throughput and combinatorial chemistry to create diverse libraries of compounds for screening against various biological targets.
• Ligand and Catalyst Preparation: Used to synthesize novel ligands for catalysis or as a scaffold for catalyst development in asymmetric synthesis.

Basic Information

Product Name	3-Bromo-5-Chloro-2-Iodotoluene
CAS No.	933671-80-8
Molecular Formula	C7H5BrClI
Molecular Weight	331.38 g/mol
Synonyms	1-Bromo-3-chloro-5-iodo-2-methylbenzene; 2-Methyl-1-bromo-3-chloro-5-iodobenzene; Toluene, 3-bromo-5-chloro-2-iodo-; 3-Bromo-5-chloro-2-iodo-1-methylbenzene
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Chloro-2-Iodotoluene is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC, GC, NMR, and elemental analysis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.