Description

Cyclobutanecarboxylic Acid, 1-(4-Chlorophenyl)-3-Hydroxy-, cis- is a high-purity, synthetically valuable chiral building block characterized by its cis-configured cyclobutane ring bearing both a carboxylic acid and a hydroxy group on adjacent carbons, with a para-chlorophenyl substituent. This unique structural motif makes it a critical intermediate for the development of novel, conformationally constrained active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily sought after by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for synthesizing compounds with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and synthesis of novel drug candidates, particularly in therapeutic areas requiring rigid, three-dimensional scaffolds.
• Agrochemical Research: Used in developing new-generation herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Potential monomer or additive for creating polymers with specific thermal or mechanical properties due to its rigid, functionalized structure.
• Academic & Contract Research: Essential compound for methodological studies in organic synthesis, particularly in ring-forming reactions and stereoselective transformations.

Basic Information

Item	Detail
Product Name	Cyclobutanecarboxylic Acid, 1-(4-Chlorophenyl)-3-Hydroxy-, cis-
CAS No.	933469-83-1
Molecular Formula	C11H11ClO3
Molecular Weight	226.66 g/mol
Synonyms	cis-1-(4-Chlorophenyl)-3-hydroxycyclobutanecarboxylic acid; (1s,3s)-1-(4-Chlorophenyl)-3-hydroxycyclobutanecarboxylic acid; 1-(4-Chlorophenyl)-3-hydroxycyclobutanecarboxylic acid (cis-); 3-Hydroxy-1-(4-chlorophenyl)cyclobutanecarboxylic acid; Cyclobutanecarboxylic acid, 1-(4-chlorophenyl)-3-hydroxy-, (1s,3s)-; (1s,3s)-1-(p-Chlorophenyl)-3-hydroxycyclobutanecarboxylic acid; cis-3-Hydroxy-1-(4-chlorophenyl)cyclobutanecarboxylic acid
EINECS	Contact for details

Quality Control

Our Cyclobutanecarboxylic Acid, 1-(4-Chlorophenyl)-3-Hydroxy-, cis- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% cis-isomer
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.