Description

n-[2-(1H-Indol-3-Yl)Ethyl]-3-(Trifluoromethyl)-[1,2,4]Triazolo[4,3-B]Pyridazin-6-Amine is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of novel active pharmaceutical ingredients (APIs). This compound is valued for its unique heterocyclic structure, combining indole and triazolopyridazine moieties, which is critical for modulating biological activity in drug discovery. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of targeted therapeutics, particularly in oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of new drug candidates, particularly for targeted cancer therapies.
• Kinase Inhibitor Synthesis: Used in the synthesis of potential kinase inhibitors due to its triazolopyridazine core, which is a privileged scaffold in medicinal chemistry.
• Biochemical Research: Serves as a reference standard or a probe molecule in biochemical assays to study protein-ligand interactions and signaling pathways.
• Preclinical Development: Employed in the scale-up synthesis of lead compounds during preclinical pharmaceutical development stages.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.

Basic Information

Product Name	n-[2-(1H-Indol-3-Yl)Ethyl]-3-(Trifluoromethyl)-[1,2,4]Triazolo[4,3-B]Pyridazin-6-Amine
CAS No.	930039-92-2
Molecular Formula	C₁₈H₁₅F₃N₆
Molecular Weight	372.35 g/mol
Synonyms	3-(Trifluoromethyl)-6-[[2-(1H-indol-3-yl)ethyl]amino]-[1,2,4]triazolo[4,3-b]pyridazine; 6-[[2-(1H-Indol-3-yl)ethyl]amino]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine; 930039-92-2; [1,2,4]Triazolo[4,3-b]pyridazin-6-amine, N-[2-(1H-indol-3-yl)ethyl]-3-(trifluoromethyl)-; N-(2-(1H-Indol-3-yl)ethyl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-amine
EINECS	Contact for details

Quality Control

Our n-[2-(1H-Indol-3-Yl)Ethyl]-3-(Trifluoromethyl)-[1,2,4]Triazolo[4,3-B]Pyridazin-6-Amine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.