Description

(R)-A-(Fmoc-Amino)Tetrahydropyran-4-Acetic Acid CAS NO 923012-63-9 is a high-purity, non-natural amino acid derivative featuring a tetrahydropyran ring and an Fmoc-protected amine group. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling the introduction of constrained, three-dimensional structural elements. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers engaged in the development of novel therapeutic agents, including protease inhibitors and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of peptides containing constrained amino acid analogs.
• Peptidomimetic Drug Discovery: Serves as a crucial scaffold for creating conformationally restricted peptide-like molecules with enhanced metabolic stability and receptor selectivity.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for targets requiring specific chiral centers and rigid backbone structures.
• Chemical Biology Probes: Incorporation into peptides for studying protein-protein interactions and enzyme mechanisms due to its unique steric and electronic properties.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse libraries of compounds for high-throughput screening in drug discovery campaigns.
• Academic & Institutional Research: Employed in synthetic organic chemistry and medicinal chemistry research for methodological development and novel compound synthesis.

Basic Information

Product Name	(R)-A-(Fmoc-Amino)Tetrahydropyran-4-Acetic Acid
CAS No.	923012-63-9
Molecular Formula	C23H25NO5
Molecular Weight	395.45 g/mol
Synonyms	(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(tetrahydro-2H-pyran-4-yl)acetic acid; Fmoc-(R)-Amino(tetrahydro-2H-pyran-4-yl)acetic Acid; (R)-Fmoc-Amino-THP-Acetic Acid; (R)-N-Fmoc-2-amino-2-(tetrahydro-2H-pyran-4-yl)acetic acid; (R)-2-(Fmoc-amino)-2-(tetrahydropyran-4-yl)acetic acid; Fmoc-D-Amino(THP)OH; (R)-N-α-Fmoc-2-amino-2-(4-tetrahydropyranyl)acetic acid
EINECS	Contact for details

Quality Control

Our (R)-A-(Fmoc-Amino)Tetrahydropyran-4-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure compliance with exacting standards for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.