Description

4-(3-Fluoro-Phenyl)-Tetrahydro-Pyran-4-Carboxylic Acid is a high-purity fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its value lies in its unique molecular architecture, which incorporates both a fluorinated aromatic ring and a carboxylic acid functional group on a saturated tetrahydropyran scaffold, enabling precise molecular modifications. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used in the design and production of advanced herbicides and fungicides, where the fluorine atom enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or metal-organic frameworks (MOFs) in asymmetric catalysis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials with tailored properties.
• Chemical Biology Probe: Utilized as a building block for fluorescent tags or molecular probes in biochemical research.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring fluorinated, complex heterocycles.

Basic Information

Product Name	4-(3-Fluoro-Phenyl)-Tetrahydro-Pyran-4-Carboxylic Acid
CAS No.	919016-93-6
Molecular Formula	C12H13FO3
Molecular Weight	224.23 g/mol
Synonyms	4-(3-Fluorophenyl)tetrahydro-2H-pyran-4-carboxylic acid; 4-(3-Fluorophenyl)oxane-4-carboxylic acid; 4-(3-Fluorophenyl)tetrahydropyran-4-carboxylic acid; 4-Carboxy-4-(3-fluorophenyl)tetrahydropyran; 919016-93-6; 4-(3-Fluoro-phenyl)-tetrahydro-pyran-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 4-(3-Fluoro-Phenyl)-Tetrahydro-Pyran-4-Carboxylic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.