Description

(S)-(1,4-Dioxan-2-yl)methyl 4-methylbenzenesulfonate is a high-purity chiral sulfonate ester building block of significant importance in advanced organic synthesis. Its primary value lies in its role as a versatile intermediate for introducing the (S)-configured 1,4-dioxane moiety into target molecules, a key structural feature in medicinal chemistry. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for creating chiral ligands, catalysts, and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs), especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced chiral pesticides and herbicides, where specific stereochemistry is crucial for biological activity and environmental safety.
• Chiral Ligand & Catalyst Preparation: Serves as a precursor for synthesizing sophisticated chiral ligands and organocatalysts used in asymmetric synthesis to create enantiomerically pure compounds.
• Material Science Research: Employed in the development of specialty polymers and functional materials where the chiral 1,4-dioxane structure imparts specific physical or chemical properties.
• Process Chemistry & Scale-up: Suitable for use in route scouting, optimization, and pilot-scale production under current Good Manufacturing Practice (cGMP) guidelines for regulated markets.

Basic Information

Product Name	(S)-(1,4-Dioxan-2-yl)methyl 4-methylbenzenesulfonate
CAS No.	917882-64-5
Molecular Formula	C13H18O5S
Molecular Weight	286.34 g/mol
Synonyms	(S)-Tosyloxymethyl-1,4-dioxane; (S)-2-((Tosyloxy)methyl)-1,4-dioxane; (S)-(1,4-Dioxan-2-yl)methyl p-toluenesulfonate; (S)-1,4-Dioxan-2-ylmethyl tosylate; p-Toluenesulfonic acid (S)-(1,4-dioxan-2-yl)methyl ester; (S)-2-(Hydroxymethyl)-1,4-dioxane tosylate; (S)-Dioxanyl methyl tosylate
EINECS	Contact for details

Quality Control

Every batch of (S)-(1,4-Dioxan-2-yl)methyl 4-methylbenzenesulfonate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as chiral purity (enantiomeric excess), chemical purity, and identity confirmation. Our quality commitment supports compliance with relevant guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.