Description

2-[2-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Ethoxy]Ethyl 1-Methanesulfonate is a specialized organosilicon-protected mesylate ester, a critical building block in advanced organic synthesis. This compound matters for its role as a key protected intermediate, enabling precise and efficient multi-step reactions in sensitive chemical environments. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Nucleoside & Nucleotide Chemistry: Used in the protection and functionalization of sugar moieties during the synthesis of modified nucleosides and oligonucleotides.
• Peptide & Carbohydrate Synthesis: Serves as a versatile reagent for introducing protected ethoxy linkers or as a leaving group in coupling reactions.
• Polymer & Material Science: Employed as a functional monomer or cross-linking agent in the development of specialty silicones and advanced polymeric materials.
• Protecting Group Strategy: The tert-butyldimethylsilyl (TBDMS) group provides orthogonal protection for alcohols in complex synthetic routes, with the mesylate offering a reactive handle for further transformation.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for biochemical and diagnostic research.

Basic Information

Product Name	2-[2-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Ethoxy]Ethyl 1-Methanesulfonate
CAS No.	917763-12-3
Molecular Formula	C12H28O5SSi
Molecular Weight	312.50 g/mol
Synonyms	2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethyl methanesulfonate; 2-[2-[(tert-Butyldimethylsilyl)oxy]ethoxy]ethyl mesylate; TBDMS-PEG2-Mesylate; (2-(2-(tert-Butyldimethylsilyloxy)ethoxy)ethyl) methanesulfonate; Ethanol, 2-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethoxy]-, 1-methanesulfonate; tert-Butyldimethyl(2-(2-(methylsulfonyloxy)ethoxy)ethoxy)silane; PEG2-TBDMS-Ms
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for high-purity synthetic intermediates. Each batch is characterized by advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specifications and test results are available upon request. We adhere to cGMP principles where applicable to support our clients in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its sensitivity to strong bases and organic solvents, keep away from incompatible materials. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.