Description

5,7-Difluorochroman-4-Ol is a fluorinated chroman derivative, a versatile chiral building block and intermediate of significant interest in advanced organic synthesis. Its value lies in the precise introduction of fluorine atoms and a hydroxyl group onto the chroman scaffold, enabling the modulation of physicochemical properties and biological activity in target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and metabolic disorder therapeutics.
• Agrochemical Synthesis: Used in the preparation of advanced pesticides and herbicides where the fluorinated chroman structure can enhance stability and efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or building block for specialty polymers and liquid crystals with unique optical properties.
• Chemical Biology Probes: Utilized in the design of molecular probes to study enzyme mechanisms and biological pathways.
• Flavor and Fragrance Industry: Potential intermediate for synthesizing novel aroma chemicals with modified scent profiles and increased stability.

Basic Information

Product Name	5,7-Difluorochroman-4-Ol
CAS No.	917248-51-2
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	5,7-Difluoro-3,4-dihydro-2H-1-benzopyran-4-ol; 4-Hydroxy-5,7-difluorochromane; 5,7-Difluoro-4-hydroxychromane; 5,7-Difluoro-3,4-dihydro-2H-chromen-4-ol; 5,7-Difluorochroman-4-ol; 4-Chromanol, 5,7-difluoro-; 5,7-Difluoro-4-hydroxy-2,3-dihydro-1-benzopyran
EINECS	Contact for details

Quality Control

Our 5,7-Difluorochroman-4-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomer specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.