Description

6-Chloro-2-Cyclopropylimidazo[1,2-B]Pyridazine is a high-purity, advanced pharmaceutical intermediate with the CAS number 916257-51-7. This heterocyclic compound is a critical building block in modern medicinal chemistry, valued for its unique fused-ring structure that enables the synthesis of novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: Used in the construction of potent and selective kinase inhibitors, a major class of oncology therapeutics.
• CNS-Active Compound Synthesis: Employed in the research and development of compounds designed to cross the blood-brain barrier for neurological applications.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for fundamental studies in heterocyclic chemistry and bioorganic chemistry.

Basic Information

Product Name	6-Chloro-2-Cyclopropylimidazo[1,2-B]Pyridazine
CAS No.	916257-51-7
Molecular Formula	C9H8ClN3
Molecular Weight	193.63 g/mol
Synonyms	6-Chloro-2-cyclopropylimidazo[1,2-b]pyridazine; 6-Chloro-2-cyclopropyl-[1,2,4]triazolo[1,5-a]pyridine (common misnomer); 2-Cyclopropyl-6-chloroimidazo[1,2-b]pyridazine; Imidazo[1,2-b]pyridazine, 6-chloro-2-cyclopropyl-; 916257-51-7; 6-Chloro-2-cyclopropylimidazopyridazine
EINECS	Contact for details

Quality Control

Our 6-Chloro-2-Cyclopropylimidazo[1,2-B]Pyridazine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with client specifications and industry best practices for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.