Description

1H-Imidazole-2-Carboxamide, 5-(Trifluoromethyl)- is a specialized trifluoromethyl-substituted imidazole derivative, serving as a high-value building block in advanced organic synthesis. Its unique structure, featuring both an imidazole heterocycle and a carboxamide group activated by an electron-withdrawing trifluoromethyl substituent, makes it a critical intermediate for developing novel compounds with enhanced properties. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for creating new active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the design and synthesis of novel pesticides and herbicides, where the trifluoromethyl group can improve metabolic stability and bioavailability.
• Material Science Research: Serves as a precursor for functionalized ligands or monomers in the development of advanced polymers and specialty materials.
• Chemical Biology Probes: Employed in the creation of molecular probes and tool compounds for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1H-Imidazole-2-Carboxamide, 5-(Trifluoromethyl)-
CAS No.	915230-42-1
Molecular Formula	C5H4F3N3O
Molecular Weight	179.10 g/mol
Synonyms	5-(Trifluoromethyl)-1H-imidazole-2-carboxamide; 5-(Trifluoromethyl)imidazole-2-carboxamide; 2-Carbamoyl-5-(trifluoromethyl)imidazole; 5-Trifluoromethyl-1H-imidazole-2-carboxylic acid amide; 1H-Imidazole-2-carboxamide, 5-(trifluoromethyl)-; 915230-42-1
EINECS	Contact for details

Quality Control

Our 1H-Imidazole-2-Carboxamide, 5-(Trifluoromethyl)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong acids, strong bases, and strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.