Description

(3S)-3-[4-[(5-Bromo-2-Chlorophenyl)Methyl]Phenoxy]Tetrahydrofuran CAS NO 915095-89-5 is a high-purity, advanced pharmaceutical intermediate characterized by its chiral tetrahydrofuran core linked to a substituted biphenylmethyl ether structure. This compound matters as a critical building block in modern organic synthesis, enabling the development of targeted active pharmaceutical ingredients (APIs) with specific stereochemical configurations. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the discovery and production of novel therapeutic agents, particularly in areas requiring complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of potential drug candidates, especially for central nervous system (CNS) or anti-inflammatory targets.
• Organic Synthesis Research: Used in academic and industrial R&D for method development, exploring new coupling reactions, and constructing complex heterocyclic systems.
• Preclinical Drug Development: Employed in the preparation of compound libraries for high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials.
• Chemical Biology Probes: Can be utilized to develop molecular probes for studying enzyme function or receptor interactions due to its specific stereochemistry and halogenated aromatic groups.

Basic Information

Item	Detail
Product Name	(3S)-3-[4-[(5-Bromo-2-Chlorophenyl)Methyl]Phenoxy]Tetrahydrofuran
CAS No.	915095-89-5
Molecular Formula	C17H16BrClO2
Molecular Weight	367.67 g/mol
Synonyms	(3S)-3-(4-((5-Bromo-2-chlorobenzyl)oxy)phenyl)tetrahydrofuran; (S)-3-(4-((5-Bromo-2-chlorobenzyl)oxy)phenyl)tetrahydrofuran; 915095-89-5; (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]oxolane; Tetrahydrofuran, 3-[4-[(5-bromo-2-chlorophenyl)methyl]phenoxy]-, (3S)-
EINECS	Contact for details

Quality Control

Our (3S)-3-[4-[(5-Bromo-2-Chlorophenyl)Methyl]Phenoxy]Tetrahydrofuran is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity, to ensure compliance with stringent specifications for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container sealed to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.