Description

(S)-(5-Bromo-2-Chlorophenyl)(4-(Tetrahydrofuran-3-Yloxy)Phenyl)Methanone is a high-purity chiral building block and advanced pharmaceutical intermediate (API intermediate) of significant commercial interest. Its complex molecular architecture, featuring a bromo-chloro substituted phenyl ring and a tetrahydrofuran-3-yloxy moiety, makes it a critical precursor in the synthesis of novel active pharmaceutical ingredients. This compound is primarily sought by pharmaceutical R&D organizations and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in areas requiring stereochemically defined scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and oncology targets.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex, stereospecific active pharmaceutical ingredients.
• Medicinal Chemistry Research: A valuable building block for constructing compound libraries in drug discovery programs to explore structure-activity relationships (SAR).
• Asymmetric Synthesis: Employed in catalytic asymmetric reactions due to its defined (S)-configuration, enabling the production of enantiomerically pure compounds.
• Fine Chemical Production: Used in the manufacture of specialty chemicals and complex organic molecules for advanced material science applications.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	(S)-(5-Bromo-2-Chlorophenyl)(4-(Tetrahydrofuran-3-Yloxy)Phenyl)Methanone
CAS No.	915095-84-0
Molecular Formula	C17H14BrClO3
Molecular Weight	381.65 g/mol
Synonyms	(S)-[5-Bromo-2-chlorophenyl][4-(oxolan-3-yloxy)phenyl]methanone; (S)-5-Bromo-2-chloro-4'-(tetrahydrofuran-3-yloxy)benzophenone; (S)-Methanone, (5-bromo-2-chlorophenyl)[4-(tetrahydro-3-furanyloxy)phenyl]-; (S)-Benzophenone, 5-bromo-2-chloro-4'-(tetrahydro-3-furanyloxy)-; 915095-84-0; (S)-enantiomer of 5-Bromo-2-chloro-4'-(3-tetrahydrofuranyloxy)benzophenone
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high chemical purity suitable for pharmaceutical research. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and chiral analysis. A Certificate of Analysis (COA) detailing identity, purity (HPLC assay), chiral purity, and impurity profiles is provided with each shipment. We support development under cGMP guidelines for projects requiring regulatory filing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (S-enantiomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.