Description

tert-Butyl 3-(2-Hydroxypropan-2-Yl)Piperidine-1-Carboxylate is a high-purity, protected piperidine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in providing a versatile chiral scaffold with orthogonal protecting groups, enabling precise and efficient construction of complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting the central nervous system (CNS).
• Agrochemical Research: Used as a precursor for developing novel pesticides and herbicides with specific stereochemical requirements.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, enzyme inhibitors, and activity-based protein profiling (ABPP) reagents.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing chiral ligands used in asymmetric hydrogenation and other enantioselective transformations.
• Custom Synthesis & Contract Manufacturing: A fundamental component for custom synthesis organizations (CSOs) and CDMOs producing bespoke compounds for client projects.
• Academic Research: Utilized in university and institutional labs for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	tert-Butyl 3-(2-Hydroxypropan-2-Yl)Piperidine-1-Carboxylate
CAS No.	914654-74-3
Molecular Formula	C13H25NO3
Molecular Weight	243.34 g/mol
Synonyms	1-Boc-3-(2-hydroxy-2-propyl)piperidine; 1-(tert-Butoxycarbonyl)-3-(2-hydroxypropan-2-yl)piperidine; 3-(2-Hydroxypropan-2-yl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 3-(1-hydroxy-1-methylethyl)piperidine-1-carboxylate; 914654-74-3; 1-Boc-3-(2-hydroxyisopropyl)piperidine; 3-(2-Hydroxy-2-propyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(2-Hydroxypropan-2-Yl)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our commitment to consistent quality and traceability supports your critical development timelines and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.