Description

1-Bromo-5-Chloro-2,4-Difluorobenzene is a high-purity, multi-halogenated benzene derivative serving as a critical building block in advanced organic synthesis. Its precise halogen substitution pattern makes it an indispensable intermediate for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials who require reliable access to high-quality, structurally defined intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, especially those containing difluorobenzene motifs for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the halogen pattern contributes to biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic and display materials, enhancing their electronic and physical properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, enabling the introduction of the bromo-chloro-difluorophenyl moiety into complex molecules.
• Functional Material Research: Employed in R&D for creating novel polymers, ligands for catalysis, and other specialty chemicals requiring specific halogenated aromatic structures.

Basic Information

Item	Details
Product Name	1-Bromo-5-Chloro-2,4-Difluorobenzene
CAS No.	914636-89-8
Molecular Formula	C6H2BrClF2
Molecular Weight	227.44 g/mol
Synonyms	2,4-Difluoro-1-bromo-5-chlorobenzene; 5-Chloro-1-bromo-2,4-difluorobenzene; 1-Bromo-5-chloro-2,4-difluorobenzol; Benzene, 1-bromo-5-chloro-2,4-difluoro-; 2-Bromo-4-chloro-1,5-difluorobenzene (isomer); BDFB (abbrev.); 5-Chloro-2,4-difluorobromobenzene
EINECS	Contact for details

Quality Control

Our production of 1-Bromo-5-Chloro-2,4-Difluorobenzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0% (Standard Grade)
Related Substances (GC/HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.