Description

4-Iodo-3-(Trifluoromethyl)Benzoic Acid is a high-value, multi-functional aromatic building block characterized by its iodine and trifluoromethyl substituents, which impart unique reactivity and physicochemical properties. This compound is essential for advanced organic synthesis, particularly in the development of complex molecules for pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the life sciences and specialty chemical industries who require precise, high-purity intermediates for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting neurological disorders and oncology, leveraging the iodine atom for further functionalization via cross-coupling reactions.
• Agrochemical Research: Used in the discovery and development of new herbicides and pesticides, where the trifluoromethyl group often enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis, useful in asymmetric synthesis and C-H activation processes.
• Material Science Precursor: Employed in the synthesis of advanced organic materials, such as liquid crystals and organic semiconductors, where its specific halogen and fluorine pattern modifies electronic properties.
• Fluorine Chemistry Building Block: Integral for introducing the trifluoromethyl moiety into complex molecular architectures, a common strategy in modern medicinal chemistry to optimize drug-like properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and reference standards.

Basic Information

Product Name	4-Iodo-3-(Trifluoromethyl)Benzoic Acid
CAS No.	914636-20-7
Molecular Formula	C8H4F3IO2
Molecular Weight	316.02 g/mol
Synonyms	3-(Trifluoromethyl)-4-iodobenzoic Acid; 4-Iodo-3-trifluoromethylbenzoic Acid; Benzoic acid, 4-iodo-3-(trifluoromethyl)-; 914636-20-7; 4-Iodo-alpha,alpha,α-trifluoro-m-toluic Acid
EINECS	Contact for details

Quality Control

Every batch of 4-Iodo-3-(Trifluoromethyl)Benzoic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by techniques such as HPLC, NMR, and mass spectrometry is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.