Description

5-Chloro-2-(Difluoromethoxy)Aniline is a versatile aromatic amine building block characterized by its chloro and difluoromethoxy substituents. This compound is valued for its role as a key intermediate in the synthesis of more complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Synthesis: Serves as a building block for creating advanced herbicides, fungicides, and insecticides, leveraging the biological activity of the difluoromethoxy group.
• Organic Synthesis: Used in various coupling reactions (e.g., Buchwald-Hartwig amination) to introduce the aniline moiety into complex molecular architectures.
• Material Science Research: Potential precursor for the synthesis of specialty polymers, liquid crystals, or advanced organic electronic materials.
• Dye and Pigment Intermediate: Can be utilized in the synthesis of specialized azo dyes and pigments requiring halogenated aniline derivatives.

Basic Information

Product Name	5-Chloro-2-(Difluoromethoxy)Aniline
CAS No.	914635-76-0
Molecular Formula	C7H6ClF2NO
Molecular Weight	193.58 g/mol
Synonyms	2-Amino-4-chloro-1-(difluoromethoxy)benzene; 4-Chloro-2-(difluoromethoxy)aniline; 5-Chloro-2-(difluoromethoxy)benzenamine; 1-Amino-5-chloro-2-(difluoromethoxy)benzene; 2-(Difluoromethoxy)-5-chloroaniline; Benzenamine, 5-chloro-2-(difluoromethoxy)-
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-(Difluoromethoxy)Aniline is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.