Description

1H-1-Ethyl Candesartan Cilexetil is a key pharmaceutical intermediate and a specific derivative of the angiotensin II receptor antagonist, Candesartan. This compound is of significant importance in the research and development of advanced cardiovascular therapeutics, particularly for hypertension and heart failure. It is primarily required by pharmaceutical R&D laboratories, API manufacturers, and fine chemical suppliers engaged in the synthesis of novel sartan-class drugs or the development of new drug delivery systems.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of Candesartan Cilexetil and its novel analogs.
• Active Pharmaceutical Ingredient (API) Research: Used in the development and process optimization for new angiotensin II receptor blockers (ARBs).
• Metabolite Studies: Serves as a reference standard or precursor in pharmacokinetic and metabolic pathway investigations.
• Process Chemistry: Employed in scaling up and refining manufacturing routes for sartan-class active ingredients.
• Analytical Standard: Utilized as a high-purity standard for quality control and method validation in analytical laboratories (HPLC, LC-MS).
• Formulation Development: Aids in the study of prodrug conversion and bioavailability enhancement in pre-formulation research.

Basic Information

Product Name	1H-1-Ethyl Candesartan Cilexetil
CAS No.	914613-35-7
Molecular Formula	C₃₃H₃₄N₆O₆
Molecular Weight	610.67 g/mol
Synonyms	1-Ethyl Candesartan Cilexetil; Candesartan Cilexetil Ethyl Derivative; 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid 1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl Ester; (1H-1-Ethyl Candesartan Cilexetil); UNII-7VMA2K1Q3J (component); Candesartan Cilexetil Impurity; Candesartan Cilexetil Related Compound
EINECS	Contact for details

Quality Control

Our 1H-1-Ethyl Candesartan Cilexetil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.