Description

N,N'-(1S)-[1,1'-Binaphthalene]-2,2'-Diylbis[N'-[3,5-Bis(Trifluoromethyl)Phenyl]-Thiourea is a sophisticated chiral thiourea derivative, recognized as a highly effective organocatalyst and chiral selector. Its value lies in its ability to facilitate asymmetric synthesis with excellent enantioselectivity, a critical requirement for producing high-purity pharmaceutical intermediates and fine chemicals. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-performance catalysts for complex synthetic routes.

Application

• Asymmetric Organocatalysis: Employed as a chiral hydrogen-bond donor catalyst for enantioselective reactions such as Michael additions, Mannich reactions, and acylations.
• Pharmaceutical Intermediate Synthesis: Critical for the enantioselective construction of chiral centers in active pharmaceutical ingredients (APIs) and drug candidates.
• Chiral Resolution & Analysis: Used as a chiral selector or stationary phase modifier in chromatography for the separation of enantiomers.
• Agrochemical Research: Applied in the asymmetric synthesis of chiral herbicides, fungicides, and plant growth regulators.
• Material Science: Investigated for the development of chiral sensors, nonlinear optical materials, and supramolecular assemblies.
• Academic & Industrial R&D: A valuable tool for methodology development in organic synthesis and catalysis research.

Basic Information

Item	Details
Product Name	N,N'-(1S)-[1,1'-Binaphthalene]-2,2'-Diylbis[N'-[3,5-Bis(Trifluoromethyl)Phenyl]-Thiourea
CAS No.	914497-25-9
Molecular Formula	C38H20F12N4S2
Molecular Weight	824.71 g/mol
Synonyms	(S)-1,1'-Binaphthalene-2,2'-diyl bis[N'-(3,5-bis(trifluoromethyl)phenyl)thiourea]; (S)-BINOL-Derived Bis(thiourea) Catalyst; (S)-3,5-Bis(trifluoromethyl)phenyl Binaphthyl Thiourea; Chiral Thiourea Organocatalyst; (S)-TRIP-Thiourea; N,N'-(1S)-1,1'-Binaphthalene-2,2'-diylbis[N'-[3,5-bis(trifluoromethyl)phenyl]thiourea]; (S)-BINAM-Thiourea Derivative; Asymmetric Hydrogen Bonding Catalyst
EINECS	Contact for details

Quality Control

Our production of N,N'-(1S)-[1,1'-Binaphthalene]-2,2'-Diylbis[N'-[3,5-Bis(Trifluoromethyl)Phenyl]-Thiourea adheres to stringent internal quality standards to ensure batch-to-batch consistency and high catalytic performance. Each lot is characterized by advanced analytical techniques, including HPLC, NMR, and chiral analysis, to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and maintain catalytic activity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.