Description

Fmoc-L-2-Amino-5-Methylhex-4-Enoic Acid is a high-purity, non-proteinogenic amino acid derivative designed for advanced peptide synthesis. This compound is critical for introducing the unique, conformationally constrained side chain of 2-amino-5-methylhex-4-enoic acid into peptide sequences under standard Fmoc solid-phase protocols. It is an essential building block for researchers and manufacturers in pharmaceutical development, particularly for creating novel peptide therapeutics, peptidomimetics, and biochemical probes where structural modification is key to enhancing biological activity and stability.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, enabling the incorporation of a sterically demanding, unsaturated side chain into custom peptide sequences.
• Pharmaceutical Research & Development: Used in the discovery and synthesis of novel peptide-based drug candidates, especially those targeting metabolic disorders, oncology, and infectious diseases.
• Peptidomimetic Design: Serves as a crucial scaffold for developing peptidomimetics, where the methylhexenyl side chain can mimic natural amino acids or introduce new pharmacophores to improve drug-like properties.
• Bioconjugation and Probe Synthesis: Utilized in the preparation of labeled peptides or affinity probes for biochemical assays, imaging, and diagnostic applications.
• Combinatorial Chemistry Libraries: An important component for generating diverse peptide libraries for high-throughput screening in drug discovery campaigns.
• Academic Research: Employed in university and institutional labs for studying protein-protein interactions, enzyme specificity, and structure-activity relationships (SAR).

Basic Information

Product Name	Fmoc-L-2-Amino-5-Methylhex-4-Enoic Acid
CAS No.	914486-08-1
Molecular Formula	C₂₂H₂₃NO₄
Molecular Weight	365.42 g/mol
Synonyms	Fmoc-Ahme-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-amino-5-methyl-4-hexenoic acid; Fmoc-2-Amino-5-methylhex-4-enoic acid; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-5-methylhex-4-enoic acid; Fmoc-L-2-Ahx(4-Me,δ⁴)-OH; Fmoc-protected 2-amino-5-methyl-4-hexenoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-L-2-Amino-5-Methylhex-4-Enoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to ensure the material meets the exacting standards required for pharmaceutical research and peptide synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.