Description

1-(4-Chloro-3-Isocyanatobenzenesulfonyl)-1,2,3,4-Tetrahydroquinoline is a specialized organic intermediate featuring a reactive isocyanate group and a sulfonyl-linked tetrahydroquinoline moiety. This compound is valued for its role as a key building block in the synthesis of complex molecules, enabling the introduction of both sulfonamide and urea/urethane functionalities. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, such as enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential drug candidates, particularly for sulfonamide-based therapeutics targeting various diseases.
• Agrochemical Synthesis: Used in research to develop new herbicides, fungicides, or insecticides with novel modes of action.
• Chemical Biology Probe Development: Serves as a versatile scaffold for creating activity-based probes to study enzyme function and protein interactions.
• Polymer & Material Science: Can be incorporated into specialty polymers, such as polyurethanes or polyureas, to impart specific chemical resistance or binding properties.
• Custom Synthesis & Contract Manufacturing: Supplied to fine chemical companies for use in custom synthesis projects and scale-up development.

Basic Information

Product Name	1-(4-Chloro-3-Isocyanatobenzenesulfonyl)-1,2,3,4-Tetrahydroquinoline
CAS No.	914349-81-8
Molecular Formula	C₁₆H₁₃ClN₂O₃S
Molecular Weight	348.80 g/mol
Synonyms	1-[(4-Chloro-3-isocyanatophenyl)sulfonyl]-1,2,3,4-tetrahydroquinoline; 4-Chloro-3-isocyanato-1-(1,2,3,4-tetrahydroquinolin-1-ylsulfonyl)benzene; 1-(4-Chloro-3-isocyanato-benzenesulfonyl)-1,2,3,4-tetrahydro-quinoline; Tetrahydroquinoline sulfonyl isocyanate derivative; 914349-81-8; 1,2,3,4-Tetrahydro-1-[(4-chloro-3-isocyanatophenyl)sulfonyl]quinoline
EINECS	Contact for details

Quality Control

Our production of 1-(4-Chloro-3-Isocyanatobenzenesulfonyl)-1,2,3,4-Tetrahydroquinoline adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from atmospheric moisture. Keep away from heat, open flames, and incompatible materials such as alcohols, amines, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isocyanate Content (Titration)	≥ 95.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.