Description

Methyl n-Boc-2-Amino-5-bromothiazole-4-carboxylate is a high-purity, protected amino acid derivative and a key synthetic intermediate in modern organic chemistry. This compound is specifically designed for the controlled synthesis of complex molecules, offering a reactive bromine handle and a Boc-protected amine for sequential functionalization. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel thiazole-based scaffolds in drug discovery and active ingredient development.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly those targeting infectious diseases, cancer, and central nervous system disorders.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that incorporate the bioactive thiazole heterocycle.
• Peptidomimetics & PROTACs: Serves as a constrained amino acid analog for creating peptide-like molecules and as a linker component in Proteolysis Targeting Chimeras (PROTACs).
• Material Science: A precursor for functionalized polymers and advanced organic materials with specific electronic or photophysical properties.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and labeled compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	Methyl n-Boc-2-Amino-5-bromothiazole-4-carboxylate
CAS No.	914349-71-6
Molecular Formula	C10H13BrN2O4S
Molecular Weight	337.19 g/mol
Synonyms	Methyl 2-[(tert-butoxycarbonyl)amino]-5-bromo-1,3-thiazole-4-carboxylate; 5-Bromo-2-[(tert-butoxycarbonyl)amino]-4-(methoxycarbonyl)thiazole; 2-(Boc-amino)-5-bromothiazole-4-carboxylic acid methyl ester; Boc-2-Abz(5-Br)-OMe; tert-Butyl (5-bromo-4-(methoxycarbonyl)thiazol-2-yl)carbamate; Methyl 5-bromo-2-[[(1,1-dimethylethoxy)carbonyl]amino]-4-thiazolecarboxylate
EINECS	Contact for details

Quality Control

Our Methyl n-Boc-2-Amino-5-bromothiazole-4-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.