Description

1-Boc-3-Hydroxymethyl-7-Nitroindole is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key protected building block for the synthesis of complex indole-based molecules, enabling precise chemical transformations. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in the fields of oncology and neurology.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing complex indole alkaloids and drug candidates targeting various disease pathways.
• Protease Inhibitor Research: Used in the development of novel inhibitors for enzymes like cathepsins and caspases, relevant in cancer and inflammatory diseases.
• Kinase Inhibitor Synthesis: Serves as a core scaffold for creating potent and selective kinase inhibitors, a major class of oncology therapeutics.
• Peptidomimetic Chemistry: Employed to construct indole-containing peptidomimetics that mimic natural peptides for enhanced stability and bioavailability.
• Material Science Research: Investigated as a precursor for functionalized polymers and organic electronic materials due to its nitro and hydroxymethyl groups.
• Agrochemical Development: Potential intermediate for creating new plant growth regulators or pesticides with indole-based structures.

Basic Information

Product Name	1-Boc-3-Hydroxymethyl-7-Nitroindole
CAS No.	914349-15-8
Molecular Formula	C₁₅H₁₈N₂O₅
Molecular Weight	306.32 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)-7-nitro-1H-indole; tert-Butyl 3-(hydroxymethyl)-7-nitro-1H-indole-1-carboxylate; 7-Nitro-1H-indole-3-methanol, 1-(1,1-dimethylethyl) 1,1-dimethylethyl ester; 1-Boc-3-(hydroxymethyl)-7-nitroindole; 1-N-Boc-3-hydroxymethyl-7-nitroindole; 3-Hydroxymethyl-7-nitroindole-1-carboxylic acid tert-butyl ester; Boc-Nitroindole-hydroxymethyl
EINECS	Contact for details

Quality Control

Our 1-Boc-3-Hydroxymethyl-7-Nitroindole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.