Description

3-Hydroxymethyl-5-Nitroindole-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key building block in the synthesis of complex heterocyclic molecules, particularly those targeting specific biological pathways. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, where consistent quality and reliable supply are paramount.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel indole-based drug candidates, including kinase inhibitors and other targeted therapies.
• Organic Synthesis Building Block: Used in medicinal chemistry for constructing complex molecular architectures, leveraging its reactive hydroxymethyl and nitro functional groups.
• Research & Development (R&D): Essential for academic and industrial R&D labs exploring new chemical entities and structure-activity relationships (SAR).
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) guidelines.
• Bioconjugation & Probe Development: Potential use in creating labeled compounds or probes for biochemical and pharmacological studies.

Basic Information

Product Name	3-Hydroxymethyl-5-Nitroindole-1-Carboxylic Acid tert-Butyl Ester
CAS No.	914349-07-8
Molecular Formula	C15H18N2O5
Molecular Weight	306.32 g/mol
Synonyms	tert-Butyl 3-(hydroxymethyl)-5-nitro-1H-indole-1-carboxylate; 1H-Indole-1-carboxylic acid, 3-(hydroxymethyl)-5-nitro-, 1,1-dimethylethyl ester; 5-Nitro-1H-indole-3-methanol, 1-(1,1-dimethylethyl) ester; 3-Hydroxymethyl-5-nitroindole-1-carboxylic acid t-butyl ester; 914349-07-8; 3-(Hydroxymethyl)-5-nitroindole-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 3-Hydroxymethyl-5-Nitroindole-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure it meets the high standards required for pharmaceutical research and development. Each batch is analyzed using advanced techniques such as HPLC, NMR, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all relevant specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, open flames, and incompatible materials. Due to its light-sensitive nature, the container should be amber-colored or stored in a dark place.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.