Description

4-(4-Acetyl-Piperazin-1-Yl)-2-Trifluoromethylaniline is a high-purity, advanced pharmaceutical intermediate featuring a unique trifluoromethyl-substituted aniline core linked to an acetylpiperazine moiety. This compound matters for its critical role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new drugs, agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of potential drug candidates, especially for central nervous system (CNS) and oncology targets.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, where the trifluoromethyl group can enhance biological activity and metabolic stability.
• Organic Synthesis: Serves as a versatile precursor for constructing complex heterocyclic compounds and functionalized aromatic systems in academic and industrial R&D.
• Ligand & Catalyst Development: The acetylpiperazine and aniline functionalities make it suitable for creating novel ligands for catalysis or as a component in material science research.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.

Basic Information

Product Name	4-(4-Acetyl-Piperazin-1-Yl)-2-Trifluoromethylaniline
CAS No.	914348-88-2
Molecular Formula	C13H16F3N3O
Molecular Weight	287.28 g/mol
Synonyms	2-Trifluoromethyl-4-(4-acetylpiperazin-1-yl)aniline; 1-[4-Amino-3-(trifluoromethyl)phenyl]-4-acetylpiperazine; 4-(4-Acetyl-1-piperazinyl)-2-(trifluoromethyl)aniline; 4-Amino-3-(trifluoromethyl)phenyl-4-acetylpiperazine; 914348-88-2; 4-(4-Acetylpiperazin-1-yl)-2-(trifluoromethyl)benzenamine; N-(4-Acetylpiperazin-1-yl)-2-trifluoromethyl-1,4-benzenediamine (incorrect but common search variant)
EINECS	Contact for details

Quality Control

Our 4-(4-Acetyl-Piperazin-1-Yl)-2-Trifluoromethylaniline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry and research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.