Description

2-(4-Acetylpiperazin-1-Yl)-4-Chlorothiazole-5-Carbaldehyde is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure combining piperazine, thiazole, and aldehyde functionalities. This compound matters for its critical role as a versatile building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. Pharmaceutical R&D teams and fine chemical manufacturers need it to develop next-generation drug candidates targeting a range of diseases, leveraging its reactive sites for further chemical elaboration.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic research.
• Agrochemical Research: Serves as a building block for developing new active ingredients in crop protection products, such as fungicides or herbicides.
• Chemical Biology & Proteomics: Utilized in the design and synthesis of chemical probes and molecular tools for studying biological pathways and protein function.
• Material Science: Potential use in the development of specialty polymers or organic electronic materials due to its conjugated system and functional groups.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and discovery chemistry projects.

Basic Information

Product Name	2-(4-Acetylpiperazin-1-Yl)-4-Chlorothiazole-5-Carbaldehyde
CAS No.	914348-66-6
Molecular Formula	C10H11ClN4O2S
Molecular Weight	286.73 g/mol
Synonyms	4-Chloro-2-(4-acetyl-1-piperazinyl)-5-thiazolecarboxaldehyde; 2-(4-Acetyl-1-piperazinyl)-4-chloro-5-thiazolecarboxaldehyde; 4-Chloro-2-(4-acetylpiperazin-1-yl)thiazole-5-carbaldehyde; 914348-66-6; 4-Chloro-2-(4-acetylpiperazino)thiazole-5-carboxaldehyde; 2-(4-Acetylpiperazin-1-yl)-4-chlorothiazole-5-carbaldehyde; 4-Chloro-2-(4-acetyl-1-piperazinyl)-1,3-thiazole-5-carbaldehyde
EINECS	Contact for details

Quality Control

Our 2-(4-Acetylpiperazin-1-Yl)-4-Chlorothiazole-5-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.