Description

n-Fmoc-2-Amino-6-Chlorobenzoic Acid CAS NO 914348-17-7 is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical key building block in the construction of complex molecules, particularly in peptide and peptidomimetic chemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery and the development of novel therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the sequential assembly of peptides, enabling the incorporation of a chlorinated aromatic side chain.
• Peptidomimetic Drug Development: Used to introduce the 2-amino-6-chlorobenzoic acid scaffold into non-peptide compounds designed to mimic peptide function with improved stability and bioavailability.
• Combinatorial Chemistry Libraries: Serves as a versatile input for generating diverse compound libraries for high-throughput screening against biological targets.
• Organic Intermediate Synthesis: Acts as a precursor for more complex heterocyclic compounds and specialized fine chemicals used in agrochemical and material science research.
• Bioconjugation and Probe Design: The carboxylic acid and amine (when deprotected) functionalities allow for conjugation to biomolecules, fluorescent tags, or solid supports for various biochemical applications.

Basic Information

Product Name	n-Fmoc-2-Amino-6-Chlorobenzoic Acid
CAS No.	914348-17-7
Molecular Formula	C22H16ClNO4
Molecular Weight	393.82 g/mol
Synonyms	2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-6-chlorobenzoic Acid; Fmoc-2-Abz(6-Cl)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-amino-6-chlorobenzoic Acid; Fmoc-2-amino-6-chlorobenzoic Acid; 6-Chloro-2-[(Fmoc-amino)]benzoic Acid; 2-(Fmoc-amino)-6-chlorobenzoic Acid; N-Fmoc-anthranilic acid, 6-chloro-; 914348-17-7
EINECS	Contact for details

Quality Control

Our n-Fmoc-2-Amino-6-Chlorobenzoic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the exacting standards required for pharmaceutical research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant cGMP guidelines for the production of advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.