Description

3-(5-Bromopyrimidin-2-Yloxy)Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a bromopyrimidine core linked to a protected pyrrolidine moiety. This compound is critically important for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel small-molecule therapeutics. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of kinase inhibitors and other targeted therapies.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for oncology and antiviral drug candidates.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: Serves as a core structural element in the design and synthesis of potent and selective kinase inhibitors due to its pyrimidine pharmacophore.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and reference standards.
• Chemical Biology Probes: Utilized in the creation of chemical probes for studying enzyme function and biological pathways in academic and industrial research settings.

Basic Information

Product Name	3-(5-Bromopyrimidin-2-Yloxy)Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	914347-79-8
Molecular Formula	C13H18BrN3O3
Molecular Weight	344.21 g/mol
Synonyms	1-Boc-3-(5-bromopyrimidin-2-yloxy)pyrrolidine; tert-Butyl 3-((5-bromopyrimidin-2-yl)oxy)pyrrolidine-1-carboxylate; 3-(5-Bromo-2-pyrimidinyloxy)-1-(tert-butoxycarbonyl)pyrrolidine; 1-(tert-Butoxycarbonyl)-3-[(5-bromopyrimidin-2-yl)oxy]pyrrolidine; 3-(5-Bromopyrimidin-2-yloxy)pyrrolidine-1-carboxylic acid tert-butyl ester; Pyrrolidine-1-carboxylic acid, 3-[(5-bromopyrimidin-2-yl)oxy]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 3-(5-Bromopyrimidin-2-Yloxy)Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.