Description

6-Fluoro-4-Hydroxychromane-2-Carboxylic Acid is a fluorinated chromane derivative that serves as a key chiral building block and intermediate in advanced organic synthesis. Its value lies in the precise molecular architecture, combining a chromane scaffold with fluorine and carboxylic acid functionalities, enabling the development of novel compounds with targeted biological activity. This intermediate is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular therapeutics.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in neurological and cardiovascular research.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and process development of potential APIs that leverage the chromane core structure.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes to study enzyme mechanisms and biological pathways.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions due to its inherent chirality.
• Process Chemistry & Scale-Up: A key material for optimizing synthetic routes from laboratory to pilot and commercial scale production.

Basic Information

Product Name	6-Fluoro-4-Hydroxychromane-2-Carboxylic Acid
CAS No.	914207-85-5
Molecular Formula	C10H9FO4
Molecular Weight	212.17 g/mol
Synonyms	6-Fluoro-4-hydroxy-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid; 2H-1-Benzopyran-2-carboxylic acid, 6-fluoro-3,4-dihydro-4-hydroxy-; 6-Fluoro-4-hydroxy-chroman-2-carboxylic acid; 6-Fluoro-4-hydroxychromane-2-carboxylic acid; 6-Fluoro-4-hydroxy-3,4-dihydro-2H-chromene-2-carboxylic acid; (4R/S)-6-Fluoro-4-hydroxychroman-2-carboxylic acid; 6-Fluoro-4-hydroxy-2-carboxychromane
EINECS	Contact for details

Quality Control

Our 6-Fluoro-4-Hydroxychromane-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomer excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.