Description

(2S)-{[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}[3-(Trifluoromethyl)Bicyclo[1.1.1]Pent-1-Yl]Acetic Acid is a sophisticated, non-natural amino acid derivative designed for advanced pharmaceutical research and development. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering unique structural constraints and metabolic stability due to its rigid bicyclo[1.1.1]pentane core and trifluoromethyl group. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for creating novel therapeutic candidates targeting challenging disease pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the solid-phase and solution-phase synthesis of constrained peptides and macrocycles.
• Protease Inhibitor Development: Used to incorporate sterically hindered, metabolically stable motifs into potential inhibitors for enzymes like proteases and kinases.
• Peptidomimetic Drug Discovery: Essential for creating peptide analogs with enhanced bioavailability, membrane permeability, and resistance to enzymatic degradation.
• Chemical Biology Probes: Serves as a building block for synthesizing activity-based probes and labeled compounds to study protein function and interactions.
• API (Active Pharmaceutical Ingredient) Synthesis: Employed in the research-scale preparation of novel active ingredients, particularly in oncology and metabolic disease research.
• Material Science Research: Potential use in creating novel polymers and biomaterials with specific structural and surface properties.

Basic Information

Product Name	(2S)-{[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}[3-(Trifluoromethyl)Bicyclo[1.1.1]Pent-1-Yl]Acetic Acid
CAS No.	914082-67-0
Molecular Formula	C23H20F3NO4
Molecular Weight	431.41 g/mol
Synonyms	Fmoc-(S)-3-(Trifluoromethyl)-Bicyclo[1.1.1]pentane-1-yl-Gly-OH; Fmoc-Bcp(3-CF3)-Gly-OH; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-[3-(trifluoromethyl)bicyclo[1.1.1]pentan-1-yl]acetic acid; Fmoc-Bcp(CF3)-Glycine; N-α-Fmoc-1-amino-3-(trifluoromethyl)bicyclo[1.1.1]pentane-1-acetic acid; Bcp(3-CF3)-Gly(Fmoc); Fmoc-Bcp(3-CF3)-Gly
EINECS	Contact for details

Quality Control

Our production of (2S)-{[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}[3-(Trifluoromethyl)Bicyclo[1.1.1]Pent-1-Yl]Acetic Acid adheres to stringent quality protocols suitable for pharmaceutical R&D applications. Each batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure high chemical and chiral purity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.