Description

(4R)-4-Fluoro-D-Proline is a non-natural, fluorinated amino acid derivative of significant interest in advanced pharmaceutical research and development. This compound matters as a key chiral building block for modulating the pharmacokinetic and metabolic properties of peptide-based therapeutics. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for applications in drug discovery and the synthesis of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel peptide drugs and protease inhibitors.
• Peptidomimetics Development: Used to incorporate fluorine into peptide backbones to enhance metabolic stability, membrane permeability, and bioavailability.
• Medicinal Chemistry Research: Serves as a building block in structure-activity relationship (SAR) studies to explore fluorination effects on biological activity.
• Bioconjugation & Probe Synthesis: Utilized in the creation of fluorinated probes for biochemical and diagnostic applications.
• Asymmetric Synthesis: Acts as a chiral auxiliary or catalyst in stereoselective organic transformations.
• API (Active Pharmaceutical Ingredient) Development: Incorporated into the final structure of investigational new drugs targeting various disease pathways.

Basic Information

Product Name	(4R)-4-Fluoro-D-Proline
CAS No.	913820-71-0
Molecular Formula	C₅H₈FNO₂
Molecular Weight	133.12 g/mol
Synonyms	D-4-Fluoroproline; (R)-4-Fluoropyrrolidine-2-carboxylic acid; (4R)-4-Fluoroproline; 4-Fluoro-D-proline; 4(R)-Fluoroproline; 4-Fluoro-(2R)-pyrrolidinecarboxylic acid; 913820-71-0; (R)-4-Fluoroprolin
EINECS	Contact for details

Quality Control

Our (4R)-4-Fluoro-D-Proline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive analytical data, including HPLC purity, chiral purity, and identification spectra. Certificates of Analysis (COA) are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.