Description

1-(3,4-Difluorophenyl)-2-Methylpropan-1-One is a high-purity fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the difluorophenyl moiety can impart desirable metabolic stability and bioavailability. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where fluorination enhances biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials and liquid crystals due to its aromatic and fluorinated structure.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, including cross-coupling and carbonyl chemistry.

Basic Information

Product Name	1-(3,4-Difluorophenyl)-2-Methylpropan-1-One
CAS No.	913719-93-4
Molecular Formula	C10H10F2O
Molecular Weight	184.18 g/mol
Synonyms	1-(3,4-Difluorophenyl)-2-methylpropan-1-one; 3',4'-Difluoro-2-methylpropiophenone; 2-Methyl-1-(3,4-difluorophenyl)propan-1-one; Isobutyryl-3,4-difluorobenzene; α,α-Dimethyl-3,4-difluoroacetophenone; 913719-93-4; 1-Propanone, 1-(3,4-difluorophenyl)-2-methyl-
EINECS	Contact for details

Quality Control

Our 1-(3,4-Difluorophenyl)-2-Methylpropan-1-One is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent batch-to-batch quality suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.