Description

(R)-4-(Pyrrolidin-3-Yl)Morpholine Dihydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. This compound is valued for its unique stereochemistry and functional group combination, which makes it a critical precursor in modern synthetic chemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, especially those targeting neurological receptors.
• Asymmetric Catalysis Ligand Precursor: Used to develop novel ligands for asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes to study biological pathways and protein function.
• Process Chemistry & Scale-Up: Used in the development and optimization of scalable synthetic routes for GMP production of APIs.

Basic Information

Product Name	(R)-4-(Pyrrolidin-3-Yl)Morpholine Dihydrochloride
CAS No.	913702-38-2
Molecular Formula	C8H18Cl2N2O
Molecular Weight	229.15 g/mol
Synonyms	(R)-4-(3-Pyrrolidinyl)morpholine dihydrochloride; (3R)-4-(3-Pyrrolidinyl)morpholine hydrochloride; Morpholine, 4-(3-pyrrolidinyl)-, (3R)-, dihydrochloride; (R)-4-Morpholin-3-yl-pyrrolidine dihydrochloride; (R)-3-Morpholin-4-ylpyrrolidine dihydrochloride; (R)-N-(3-Pyrrolidinyl)morpholine dihydrochloride
EINECS	Contact for details

Quality Control

We supply (R)-4-(Pyrrolidin-3-Yl)Morpholine Dihydrochloride in high-purity grades suitable for research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing parameters such as chiral purity, assay, and impurity profiles. We adhere to strict internal quality management protocols to ensure batch-to-batch consistency and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.