Description

1-(3R)-3-Pyrrolidinyl-Piperidine Dihydrochloride is a high-purity chiral building block and intermediate of significant importance in modern pharmaceutical research and development. Its defined stereochemistry and piperidine-pyrrolidine scaffold make it a valuable precursor for synthesizing complex, biologically active molecules. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery and development of new therapeutic agents, particularly within the fields of central nervous system (CNS) disorders and other receptor-targeted therapies.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates targeting neurological receptors.
• Medicinal Chemistry Research: Used as a core scaffold or building block for constructing novel compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Ligand Synthesis: Employed in the development of selective ligands for various G-protein coupled receptors (GPCRs) and other protein targets.
• Process Chemistry & Scale-up: Serves as a critical intermediate during the optimization and pilot-scale production of active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized in chiral pool synthesis due to its fixed (3R) stereocenter, enabling the construction of enantiomerically pure final products.

Basic Information

Product Name	1-(3R)-3-Pyrrolidinyl-Piperidine Dihydrochloride
CAS No.	913702-35-9
Molecular Formula	C9H20Cl2N2
Molecular Weight	227.18 g/mol
Synonyms	(R)-1-(Piperidin-1-yl)pyrrolidin-3-amine dihydrochloride; (3R)-1-(1-Piperidinyl)-3-pyrrolidinamine dihydrochloride; 1-[(3R)-3-Aminopyrrolidin-1-yl]piperidine dihydrochloride; (R)-3-Amino-1-(piperidin-1-yl)pyrrolidine dihydrochloride; 1-((R)-3-Aminopyrrolidin-1-yl)piperidine dihydrochloride; (R)-1-(Piperidin-1-yl)pyrrolidin-3-amine hydrochloride (1:2); 913702-35-9
EINECS	Contact for details

Quality Control

Our 1-(3R)-3-Pyrrolidinyl-Piperidine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.