Description

4-Fluoro-n-Piperidin-4-Ylbenzenesulfonamide Hydrochloride CAS NO 913634-50-1 is a high-purity, sulfonamide-based organic building block with a piperidine core, offered as a hydrochloride salt for enhanced stability and handling. This compound is a critical intermediate in modern pharmaceutical research and development, valued for its role in creating novel bioactive molecules. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of potential drug candidates targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new chemical entities (NCEs) for drug discovery programs.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to develop compounds with improved potency and selectivity.
• Protease Inhibitor Development: The sulfonamide and piperidine motifs make it a valuable scaffold for designing inhibitors of various enzymes, including proteases.
• Kinase Inhibitor Research: Serves as a core structure in the development of small molecule kinase inhibitors for oncology and inflammatory diseases.
• Chemical Biology Probes: Utilized in the creation of tool compounds to study biological pathways and target validation.
• Process Chemistry: Employed in route scouting and scale-up synthesis for active pharmaceutical ingredient (API) manufacturing under GMP conditions.

Basic Information

Product Name	4-Fluoro-n-Piperidin-4-Ylbenzenesulfonamide Hydrochloride
CAS No.	913634-50-1
Molecular Formula	C11H16FN3O2S • HCl
Molecular Weight	309.79 g/mol (Free base: 273.33 g/mol)
Synonyms	4-Fluoro-N-(piperidin-4-yl)benzenesulfonamide hydrochloride; 4-Fluoro-N-(4-piperidinyl)benzenesulfonamide HCl; 4-Fluoro-N-(piperidin-4-yl)benzene-1-sulfonamide hydrochloride; 913634-50-1; Benzenesulfonamide, 4-fluoro-N-4-piperidinyl-, hydrochloride; 4-Fluoro-N-piperidin-4-yl-benzenesulfonamide HCl; 4-Fluoro-N-(4-piperidyl)benzenesulfonamide hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Fluoro-n-Piperidin-4-Ylbenzenesulfonamide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with complete batch data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.