Description

tert-Butyl (1S,2R)-2-Hydroxycyclopentylcarbamate is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic utility. This compound is valued for its defined stereochemistry, which is critical for the enantioselective synthesis of complex bioactive molecules. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in areas such as antiviral, anticancer, and central nervous system (CNS) active agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Protease Inhibitor Synthesis: Used in the research and development of protease inhibitors, including those targeting viral proteases.
• Peptidomimetic Chemistry: Serves as a constrained scaffold for constructing peptidomimetics and macrocyclic compounds.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric transformations to introduce stereogenic centers.
• Medicinal Chemistry Research: Utilized in structure-activity relationship (SAR) studies and lead optimization programs in drug discovery.
• Custom Synthesis & Contract Manufacturing: Supplied for custom chemical synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	tert-Butyl (1S,2R)-2-Hydroxycyclopentylcarbamate
CAS No.	913631-66-0
Molecular Formula	C10H19NO3
Molecular Weight	201.26 g/mol
Synonyms	(1S,2R)-2-[(tert-Butoxycarbonyl)amino]cyclopentanol; (1S,2R)-N-Boc-2-aminocyclopentanol; (1S,2R)-2-(Boc-amino)cyclopentanol; tert-Butyl N-[(1S,2R)-2-hydroxycyclopentyl]carbamate; (1S,2R)-2-Hydroxycyclopentylcarbamic acid tert-butyl ester; BOC-(1S,2R)-2-Aminocyclopentanol; (1S,2R)-2-Amino-1-cyclopentanol tert-butylcarbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl (1S,2R)-2-Hydroxycyclopentylcarbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.