Description

2-(4-Bromophenyl)-2,2-Difluoroacetic Acid is a high-purity, specialized fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique difluoroacetic acid moiety attached to a brominated phenyl ring, enabling precise molecular modifications in complex chemical architectures. It is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, material science, and as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in the development of fluorine-containing bioactive molecules.
• Agrochemical Research: Used in the creation of advanced herbicides, fungicides, and pesticides where the difluoro and bromo substituents confer specific biological activity and stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced organic materials.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization due to its ability to modulate the physicochemical properties of target molecules.
• Chemical Synthesis Reagent: Acts as a versatile reagent for introducing the 2,2-difluoroacetic acid group into complex aromatic systems via further cross-coupling or functional group transformations.
• Ligand and Catalyst Development: Utilized in the preparation of novel ligands for catalysis or as a component in metal-organic frameworks (MOFs).

Basic Information

Product Name	2-(4-Bromophenyl)-2,2-Difluoroacetic Acid
CAS No.	913574-93-3
Molecular Formula	C8H5BrF2O2
Molecular Weight	251.03 g/mol
Synonyms	2,2-Difluoro-2-(4-bromophenyl)acetic Acid; α,α-Difluoro-4-bromophenylacetic Acid; 4-Bromo-α,α-difluorophenylacetic Acid; (4-Bromophenyl)difluoroacetic Acid; 2-(p-Bromophenyl)-2,2-difluoroacetic Acid; 913574-93-3; p-Bromophenyl(difluoro)acetic Acid
EINECS	Contact for details

Quality Control

Our production of 2-(4-Bromophenyl)-2,2-Difluoroacetic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical parameters. Our quality systems are designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from incompatible materials such as strong bases, oxidizing agents, and reactive metals. Ensure the container is kept upright to prevent leakage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.