Description

1H-Indole-1-Carboxylic Acid, 2-Borono-5-[[4-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]-1-Piperidinyl]Methyl]-, 1-(1,1-Dimethylethyl) Ester is a sophisticated, multi-functional organic compound featuring indole, boronic acid, and silyl-protected piperidine moieties. This complex structure makes it a highly valuable building block for advanced organic synthesis, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists working on novel drug candidates, especially in areas requiring precise molecular modifications and cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug molecules, particularly those targeting the central nervous system (CNS) or requiring boron-based functionalities.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic acid ester group serves as a key reagent for forming carbon-carbon bonds, a fundamental step in constructing complex organic architectures.
• Protease Inhibitor Research: The indole scaffold is a common motif in the development of protease inhibitors, making this compound valuable for medicinal chemistry programs in virology and oncology.
• Chemical Biology & Probe Development: Used to create molecular probes for studying enzyme function and biological pathways due to its modifiable functional groups.
• Process Chemistry & Scale-Up: Employed in the development and optimization of synthetic routes for active pharmaceutical ingredients (APIs) at pilot and commercial scales.
• Academic Research: Serves as a specialized reagent in university and institutional labs for pioneering synthetic methodology and novel compound library generation.

Basic Information

Product Name	1H-Indole-1-Carboxylic Acid, 2-Borono-5-[[4-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]-1-Piperidinyl]Methyl]-, 1-(1,1-Dimethylethyl) Ester
CAS No.	913388-71-3
Molecular Formula	C27H45BN2O4Si
Molecular Weight	500.56 g/mol
Synonyms	2-Borono-5-((4-(((tert-butyldimethylsilyl)oxy)methyl)piperidin-1-yl)methyl)-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 2-borono-5-((4-(((tert-butyldimethylsilyl)oxy)methyl)piperidin-1-yl)methyl)-1H-indole-1-carboxylate; 1-(tert-Butyl) 2-borono-5-[[4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-piperidinyl]methyl]-1H-indole-1-carboxylate; TBDMS-protected Boronic Acid Indole Ester; CAS 913388-71-3
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our GMP-compliant documentation and commitment to traceability support its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.