Description

1H-Indole-1-Carboxylic Acid, 2-Borono-5-[[1-[(1,1-Dimethylethoxy)Carbonyl]-4-Piperidinyl]Amino]-, 1-(1,1-Dimethylethyl) Ester CAS NO 913388-67-7 is a sophisticated boronic acid derivative and protected intermediate of significant interest in advanced organic synthesis. This compound is engineered to provide a reactive handle for Suzuki-Miyaura cross-coupling reactions while offering orthogonal protection for the indole nitrogen and piperidine amine, enabling precise, sequential synthetic strategies. It is primarily utilized by medicinal chemistry and process development teams in the pharmaceutical and biotechnology sectors for the research and development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex molecules in drug discovery programs, particularly for kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boronic acid/ester partner for palladium-catalyzed carbon-carbon bond formation to construct biaryl and heterobiaryl scaffolds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize the biological activity of lead compounds.
• Process Chemistry Development: Employed in route scouting and scale-up optimization for the production of active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Facilitates the creation of labeled or tagged molecules for studying biological pathways and target engagement.
• Library Synthesis: Enables the generation of diverse compound libraries for high-throughput screening in early-stage drug discovery.

Basic Information

Product Name	1H-Indole-1-Carboxylic Acid, 2-Borono-5-[[1-[(1,1-Dimethylethoxy)Carbonyl]-4-Piperidinyl]Amino]-, 1-(1,1-Dimethylethyl) Ester
CAS No.	913388-67-7
Molecular Formula	C24H36BN3O5
Molecular Weight	457.37 g/mol
Synonyms	2-Borono-5-[(1-Boc-4-piperidinyl)amino]-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl 2-borono-5-[(1-Boc-4-piperidinyl)amino]-1H-indole-1-carboxylate; 5-[(1-Boc-4-piperidinyl)amino]-1-(tert-butoxycarbonyl)-1H-indole-2-boronic acid pinacol ester (protected form analog); BOC-Indole-Boronic Acid Piperidine Derivative; (1-(tert-Butoxycarbonyl)-5-((1-(tert-butoxycarbonyl)piperidin-4-yl)amino)-1H-indol-2-yl)boronic acid; CAS 913388-67-7; Boronate Ester Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is characterized by HPLC, NMR, and mass spectrometry to confirm identity and purity. We provide comprehensive Certificates of Analysis (COA) detailing all relevant specifications, supporting compliance with internal quality standards for pharmaceutical R&D. Custom purity grades and analytical packages are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95% (Standard Grade)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.