Description

(R)-2-((R)-6,7-Dimethoxy-1-(4-(Trifluoromethyl)Phenethyl)-3,4-Dihydroisoquinolin-2(1H)-Yl)-n-Methyl-2-Phenylacetamide is a high-purity, chiral pharmaceutical intermediate of significant commercial interest. This compound matters for its role as a critical building block in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly those targeting neurological and cardiovascular pathways. Pharmaceutical R&D teams and fine chemical manufacturers need this material for process development and scale-up activities requiring strict stereochemical control and reliable supply chain integrity.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the research and development of novel therapeutic agents.
• Neurological Drug Synthesis: Used in the synthesis of compounds targeting specific receptors within the central nervous system.
• Cardiovascular API Production: Serves as a building block for active ingredients in cardiovascular disease treatments.
• Asymmetric Catalysis Research: Employed as a substrate or ligand in studies exploring new chiral synthesis methodologies.
• Process Chemistry & Scale-Up: Critical for optimizing and scaling synthetic routes from laboratory to pilot and commercial production.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	(R)-2-((R)-6,7-Dimethoxy-1-(4-(Trifluoromethyl)Phenethyl)-3,4-Dihydroisoquinolin-2(1H)-Yl)-n-Methyl-2-Phenylacetamide
CAS No.	913358-93-7
Molecular Formula	C30H31F3N2O3
Molecular Weight	524.58 g/mol
Synonyms	(R)-N-Methyl-2-((R)-6,7-dimethoxy-1-(4-(trifluoromethyl)phenethyl)-1,2,3,4-tetrahydroisoquinolin-2-yl)-2-phenylacetamide; (R,R)-913358-93-7; UNII-9V1H5R4S0K; 9V1H5R4S0K; (2R)-2-[(6R)-6,7-Dimethoxy-1-[2-[4-(trifluoromethyl)phenyl]ethyl]-3,4-dihydro-1H-isoquinolin-2-yl]-N-methyl-2-phenylacetamide; (R)-2-[(R)-6,7-Dimethoxy-1-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,2,3,4-tetrahydroisoquinolin-2-yl]-N-methyl-2-phenylacetamide
EINECS	Contact for details

Quality Control

Our (R)-2-((R)-6,7-Dimethoxy-1-(4-(Trifluoromethyl)Phenethyl)-3,4-Dihydroisoquinolin-2(1H)-Yl)-n-Methyl-2-Phenylacetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.