Description

(3Ar,4S,5R,6As)-4-(Hydroxymethyl)-5-(Triethylsilyloxy)-Hexahydro-Cyclopentafuran-2-One CAS NO 913258-07-8 is a high-purity, advanced pharmaceutical intermediate featuring a complex, stereochemically defined cyclopentafuranone core. This compound is critical for the synthesis of novel, potent active pharmaceutical ingredients (APIs), particularly in antiviral and oncology research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing sophisticated molecular architectures.

Application

• Key Intermediate in Antiviral Drug Synthesis: Serves as a crucial chiral building block for the development of nucleoside analog prodrugs and other antiviral therapeutics.
• Oncology Research & API Development: Used in the construction of complex scaffolds for targeted cancer therapies and kinase inhibitors.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial manufacturing of high-value pharmaceuticals.
• Asymmetric Synthesis: Utilized as a chiral synthon to introduce specific stereocenters in complex natural product synthesis and medicinal chemistry programs.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) producing bespoke compounds for client pipelines.

Basic Information

Product Name	(3Ar,4S,5R,6As)-4-(Hydroxymethyl)-5-(Triethylsilyloxy)-Hexahydro-Cyclopentafuran-2-One
CAS No.	913258-07-8
Molecular Formula	C15H28O4Si
Molecular Weight	300.47 g/mol
Synonyms	4-(Hydroxymethyl)-5-(triethylsilyloxy)hexahydrocyclopenta[b]furan-2(3H)-one; Hexahydro-4-(hydroxymethyl)-5-[(triethylsilyl)oxy]cyclopenta[b]furan-2(3H)-one; TES-protected cyclopentafuranone intermediate; (3aR,4S,5R,6aS)-4-(Hydroxymethyl)-5-[(triethylsilyl)oxy]hexahydrocyclopenta[b]furan-2(3H)-one; Chiral silyl ether furanone
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and stereochemical integrity. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from chiral HPLC, NMR, and mass spectrometry. Our quality commitment supports compliance with cGMP guidelines for pharmaceutical starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.