Description

tert-Butyl 6-Amino-7-Chloro-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a high-purity, protected heterocyclic amine building block of significant importance in modern organic synthesis. This compound is valued for its role as a versatile intermediate in the development of complex, biologically active molecules. It is primarily sought after by pharmaceutical R&D and fine chemical manufacturers for constructing key scaffolds in drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular targets.
• Medicinal Chemistry Research: Serves as a critical scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Organic Synthesis Building Block: Used in multi-step synthesis for constructing complex isoquinoline and tetrahydroisoquinoline derivatives.
• Agrochemical Development: Potential intermediate in the research and synthesis of novel crop protection agents and herbicides.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	tert-Butyl 6-Amino-7-Chloro-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	912846-75-4
Molecular Formula	C14H17ClN2O2
Molecular Weight	280.75 g/mol
Synonyms	6-Amino-7-chloro-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; 2(1H)-Isoquinolinecarboxylic acid, 6-amino-7-chloro-3,4-dihydro-, 1,1-dimethylethyl ester; tert-Butyl 6-amino-7-chloro-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; 6-Amino-7-chloro-3,4-dihydro-2(1H)-isoquinolinecarboxylic acid tert-butyl ester; Boc-6-Amino-7-chloro-THIQ; 7-Chloro-6-amino-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Amino-7-Chloro-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be handled with appropriate precautions for strong acid/organic solvent compatibility. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.