Description

tert-Butyl7-Chloro-6-Nitro-3,4-Dihydroisoquinoline-2(1H)-Carboxylate CAS NO 912846-74-3 is a high-purity, protected heterocyclic building block essential for advanced organic synthesis. This compound is a critical intermediate in the development of novel pharmaceutical agents, particularly in the research and production of complex small molecule therapeutics. It is primarily needed by R&D laboratories, process development chemists, and manufacturers in the pharmaceutical and agrochemical industries for constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Agrochemical Synthesis: Employed as a building block for developing novel herbicides, fungicides, and plant growth regulators.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of specialized fine chemicals and custom molecules.
• Academic Research: Utilized in university and institutional laboratories for methodological development and the study of heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl7-Chloro-6-Nitro-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	912846-74-3
Molecular Formula	C₁₄H₁₅ClN₂O₄
Molecular Weight	310.73 g/mol
Synonyms	tert-Butyl 7-chloro-6-nitro-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; 2-(tert-Butoxycarbonyl)-7-chloro-6-nitro-1,2,3,4-tetrahydroisoquinoline; 7-Chloro-6-nitro-3,4-dihydroisoquinoline-2(1H)-carboxylic acid tert-butyl ester; Boc-7-chloro-6-nitro-THIQ; 912846-74-3; tert-Butyl 7-chloro-6-nitro-3,4-dihydro-1H-isoquinoline-2-carboxylate; 1,2,3,4-Tetrahydro-7-chloro-6-nitroisoquinoline-2-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl7-Chloro-6-Nitro-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to light and potential for oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.