Description

1-(3-Fluoro-Benzoylamino)-Cyclohexanecarboxylic Acid is a high-purity, non-natural amino acid derivative featuring a cyclohexane backbone and a fluorinated benzamide moiety. This compound serves as a critical pharmaceutical intermediate and custom synthesis building block for research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate specific steric and electronic properties into novel molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore the impact of fluorination and conformational restriction on bioactivity.
• Peptidomimetic Synthesis: Serves as a constrained, non-proteinogenic amino acid analog for developing peptide-like compounds with enhanced metabolic stability and bioavailability.
• Agrochemical Development: Intermediate in the research and production of advanced herbicides and fungicides where the fluorine atom and rigid structure can improve efficacy and environmental profile.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.
• Chemical Biology Probes: Utilized in the development of chemical probes and tools for studying enzyme function and biological pathways.

Basic Information

Product Name	1-(3-Fluoro-Benzoylamino)-Cyclohexanecarboxylic Acid
CAS No.	912771-16-5
Molecular Formula	C14H16FNO3
Molecular Weight	265.28 g/mol
Synonyms	1-[(3-Fluorobenzoyl)amino]cyclohexanecarboxylic acid; Cyclohexanecarboxylic acid, 1-[(3-fluorobenzoyl)amino]-; N-(3-Fluorobenzoyl)-1-aminocyclohexanecarboxylic acid; 1-Amino-N-(3-fluorobenzoyl)cyclohexanecarboxylic acid; 3-Fluoro-N-(1-carboxycyclohexyl)benzamide; Fmoc-1-Amcha(3-F)-OH (precursor); (1-Aminocyclohexyl)(3-fluorophenyl)methanone carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(3-Fluoro-Benzoylamino)-Cyclohexanecarboxylic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.