Description

(2-Amino-2-Benzo[1,3]Dioxol-5-Yl-Ethyl)-Carbamic Acid tert-Butyl Ester is a protected amino acid derivative featuring a 1,3-benzodioxole (piperonyl) moiety and a tert-butyloxycarbonyl (Boc) protecting group. This compound is a critical chiral building block in the synthesis of complex organic molecules, particularly in pharmaceutical research and development. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of potential drug candidates, especially those targeting the central nervous system.
• Peptidomimetics Research: Used to incorporate the 1,3-benzodioxole structural motif into peptide backbones to enhance metabolic stability and binding affinity.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore new chemical entities with therapeutic potential.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric transformations to construct complex chiral centers.
• Chemical Biology: Acts as a building block for the synthesis of molecular probes and tool compounds used in biochemical assays.
• Custom Synthesis: Supplied to fine chemical companies for the contract manufacturing of specialized, high-value intermediates.

Basic Information

Product Name	(2-Amino-2-Benzo[1,3]Dioxol-5-Yl-Ethyl)-Carbamic Acid tert-Butyl Ester
CAS No.	912762-94-8
Molecular Formula	C14H18N2O4
Molecular Weight	278.30 g/mol
Synonyms	Boc-1,3-Benzodioxole-5-glycine; N-(tert-Butoxycarbonyl)-2-amino-2-(1,3-benzodioxol-5-yl)acetic acid; tert-Butyl N-[2-amino-2-(1,3-benzodioxol-5-yl)ethyl]carbamate; 2-(Boc-amino)-2-(1,3-benzodioxol-5-yl)acetic acid; 2-[(tert-Butoxycarbonyl)amino]-2-(1,3-benzodioxol-5-yl)acetic acid; (2-Amino-2-(1,3-benzodioxol-5-yl)ethyl)carbamic acid tert-butyl ester; (R/S)-N-Boc-1,3-benzodioxole-5-glycine
EINECS	Contact for details

Quality Control

Our (2-Amino-2-Benzo[1,3]Dioxol-5-Yl-Ethyl)-Carbamic Acid tert-Butyl Ester is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting critical parameters such as assay, chiral purity, and impurity profiles. Our quality commitment supports compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.