Description

1-tert-Butyl 4-Ethyl 5-Hydroxyazepane-1,4-Dicarboxylate is a high-purity, functionalized azepane derivative serving as a critical chiral building block and advanced pharmaceutical intermediate. Its value lies in its unique stereochemistry and functional group array, enabling the synthesis of complex molecules with high selectivity. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries, particularly for constructing novel active ingredients and exploring new synthetic pathways.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and metabolic disorder therapeutics.
• Agrochemical Synthesis: Building block for creating novel, high-efficacy pesticides and herbicides with specific stereochemical requirements.
• Asymmetric Catalysis Research: Valuable ligand precursor or substrate in the development and study of new asymmetric catalytic reactions.
• Peptidomimetics & Bioactive Molecule Design: Core structure for designing conformationally constrained peptide analogs and other bioactive compounds.
• Academic & Industrial R&D: Essential material for medicinal chemistry programs and process chemistry optimization in laboratory and pilot-scale settings.
• Custom Synthesis Starting Point: High-value starting material for contract research and manufacturing organizations (CROs/CMOs) performing bespoke chemical synthesis.

Basic Information

Product Name	1-tert-Butyl 4-Ethyl 5-Hydroxyazepane-1,4-Dicarboxylate
CAS No.	912444-87-2
Molecular Formula	C14H25NO5
Molecular Weight	287.35 g/mol
Synonyms	5-Hydroxyazepane-1,4-dicarboxylic acid 1-tert-butyl 4-ethyl ester; 1-(tert-Butoxycarbonyl)-4-(ethoxycarbonyl)-5-hydroxyazepane; Ethyl 1-(tert-butoxycarbonyl)-5-hydroxyazepane-4-carboxylate; 5-Hydroxy-1,4-azepanedicarboxylic acid 1-tert-butyl 4-ethyl ester; Azepane-1,4-dicarboxylic acid, 5-hydroxy-, 1-tert-butyl 4-ethyl ester; BOC-Aze(5-OH)-OEt; (4R,5S)-1-tert-Butyl 4-ethyl 5-hydroxyazepane-1,4-dicarboxylate (stereoisomer)
EINECS	Contact for details

Quality Control

Our production of 1-tert-Butyl 4-Ethyl 5-Hydroxyazepane-1,4-Dicarboxylate adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the exacting standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.